GlutaredoxinV1, Main, Exploration, bibRecord, 000195

A fungal ABC transporter FgAtm1 regulates iron homeostasis via the transcription factor cascade FgAreA-HapX.

Identifieur interne : 000195 ( Main/Exploration ); précédent : 000194; suivant : 000196

A fungal ABC transporter FgAtm1 regulates iron homeostasis via the transcription factor cascade FgAreA-HapX.

Auteurs : Zhihui Wang [République populaire de Chine] ; Tianling Ma [République populaire de Chine] ; Yunyan Huang [République populaire de Chine] ; Jing Wang [République populaire de Chine] ; Yun Chen [République populaire de Chine] ; H Corby Kistler [États-Unis] ; Zhonghua Ma [République populaire de Chine] ; Yanni Yin [République populaire de Chine]

Source :

PLoS pathogens [ 1553-7374 ] ; 2019.

RBID : pubmed:31545842

Descripteurs français

English descriptors

KwdEn :
- ATP-Binding Cassette Transporters (genetics), ATP-Binding Cassette Transporters (metabolism), Base Sequence (MeSH), DNA, Fungal (genetics), Edible Grain (microbiology), Fungal Proteins (genetics), Fungal Proteins (metabolism), Fusarium (genetics), Fusarium (metabolism), Fusarium (pathogenicity), Gene Deletion (MeSH), Genes, Fungal (MeSH), Homeostasis (MeSH), Iron (metabolism), Iron-Sulfur Proteins (genetics), Iron-Sulfur Proteins (metabolism), Models, Biological (MeSH), Mutation (MeSH), Plant Diseases (microbiology), Protein-Serine-Threonine Kinases (genetics), Protein-Serine-Threonine Kinases (metabolism), Siderophores (genetics), Siderophores (metabolism), Stress, Physiological (MeSH).
MESH :
- chemical , genetics : ATP-Binding Cassette Transporters, DNA, Fungal, Fungal Proteins, Iron-Sulfur Proteins, Protein-Serine-Threonine Kinases, Siderophores.
- chemical , metabolism : ATP-Binding Cassette Transporters, Fungal Proteins, Iron, Iron-Sulfur Proteins, Protein-Serine-Threonine Kinases, Siderophores.
- genetics : Fusarium.
- metabolism : Fusarium.
- microbiology : Edible Grain, Plant Diseases.
- pathogenicity : Fusarium.
- Base Sequence, Gene Deletion, Genes, Fungal, Homeostasis, Models, Biological, Mutation, Stress, Physiological.

Abstract

Iron homeostasis is important for growth, reproduction and other metabolic processes in all eukaryotes. However, the functions of ATP-binding cassette (ABC) transporters in iron homeostasis are largely unknown. Here, we found that one ABC transporter (named FgAtm1) is involved in regulating iron homeostasis, by screening sensitivity to iron stress for 60 ABC transporter mutants of Fusarium graminearum, a devastating fungal pathogen of small grain cereal crops worldwide. The lack of FgAtm1 reduces the activity of cytosolic Fe-S proteins nitrite reductase and xanthine dehydrogenase, which causes high expression of FgHapX via activating transcription factor FgAreA. FgHapX represses transcription of genes for iron-consuming proteins directly but activates genes for iron acquisition proteins by suppressing another iron regulator FgSreA. In addition, the transcriptional activity of FgHapX is regulated by the monothiol glutaredoxin FgGrx4. Furthermore, the phosphorylation of FgHapX, mediated by the Ser/Thr kinase FgYak1, is required for its functions in iron homeostasis. Taken together, this study uncovers a novel regulatory mechanism of iron homeostasis mediated by an ABC transporter in an important pathogenic fungus.

DOI: 10.1371/journal.ppat.1007791
PubMed: 31545842
PubMed Central: PMC6788720

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000110
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Le document en format XML

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<author><name sortKey="Chen, Yun" sort="Chen, Yun" uniqKey="Chen Y" first="Yun" last="Chen">Yun Chen</name>
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<author><name sortKey="Yin, Yanni" sort="Yin, Yanni" uniqKey="Yin Y" first="Yanni" last="Yin">Yanni Yin</name>
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<idno type="eISSN">1553-7374</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ATP-Binding Cassette Transporters (genetics)</term>
<term>ATP-Binding Cassette Transporters (metabolism)</term>
<term>Base Sequence (MeSH)</term>
<term>DNA, Fungal (genetics)</term>
<term>Edible Grain (microbiology)</term>
<term>Fungal Proteins (genetics)</term>
<term>Fungal Proteins (metabolism)</term>
<term>Fusarium (genetics)</term>
<term>Fusarium (metabolism)</term>
<term>Fusarium (pathogenicity)</term>
<term>Gene Deletion (MeSH)</term>
<term>Genes, Fungal (MeSH)</term>
<term>Homeostasis (MeSH)</term>
<term>Iron (metabolism)</term>
<term>Iron-Sulfur Proteins (genetics)</term>
<term>Iron-Sulfur Proteins (metabolism)</term>
<term>Models, Biological (MeSH)</term>
<term>Mutation (MeSH)</term>
<term>Plant Diseases (microbiology)</term>
<term>Protein-Serine-Threonine Kinases (genetics)</term>
<term>Protein-Serine-Threonine Kinases (metabolism)</term>
<term>Siderophores (genetics)</term>
<term>Siderophores (metabolism)</term>
<term>Stress, Physiological (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ADN fongique (génétique)</term>
<term>Délétion de gène (MeSH)</term>
<term>Fer (métabolisme)</term>
<term>Ferrosulfoprotéines (génétique)</term>
<term>Ferrosulfoprotéines (métabolisme)</term>
<term>Fusarium (génétique)</term>
<term>Fusarium (métabolisme)</term>
<term>Fusarium (pathogénicité)</term>
<term>Grains comestibles (microbiologie)</term>
<term>Gènes fongiques (MeSH)</term>
<term>Homéostasie (MeSH)</term>
<term>Maladies des plantes (microbiologie)</term>
<term>Modèles biologiques (MeSH)</term>
<term>Mutation (MeSH)</term>
<term>Protein-Serine-Threonine Kinases (génétique)</term>
<term>Protein-Serine-Threonine Kinases (métabolisme)</term>
<term>Protéines fongiques (génétique)</term>
<term>Protéines fongiques (métabolisme)</term>
<term>Sidérophores (génétique)</term>
<term>Sidérophores (métabolisme)</term>
<term>Stress physiologique (MeSH)</term>
<term>Séquence nucléotidique (MeSH)</term>
<term>Transporteurs ABC (génétique)</term>
<term>Transporteurs ABC (métabolisme)</term>
</keywords>
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<term>DNA, Fungal</term>
<term>Fungal Proteins</term>
<term>Iron-Sulfur Proteins</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Siderophores</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>ATP-Binding Cassette Transporters</term>
<term>Fungal Proteins</term>
<term>Iron</term>
<term>Iron-Sulfur Proteins</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Siderophores</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Fusarium</term>
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<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ADN fongique</term>
<term>Ferrosulfoprotéines</term>
<term>Fusarium</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Protéines fongiques</term>
<term>Sidérophores</term>
<term>Transporteurs ABC</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Fusarium</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Grains comestibles</term>
<term>Maladies des plantes</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Edible Grain</term>
<term>Plant Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Fer</term>
<term>Ferrosulfoprotéines</term>
<term>Fusarium</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Protéines fongiques</term>
<term>Sidérophores</term>
<term>Transporteurs ABC</term>
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<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Fusarium</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Fusarium</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Base Sequence</term>
<term>Gene Deletion</term>
<term>Genes, Fungal</term>
<term>Homeostasis</term>
<term>Models, Biological</term>
<term>Mutation</term>
<term>Stress, Physiological</term>
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<term>Gènes fongiques</term>
<term>Homéostasie</term>
<term>Modèles biologiques</term>
<term>Mutation</term>
<term>Stress physiologique</term>
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<front><div type="abstract" xml:lang="en">Iron homeostasis is important for growth, reproduction and other metabolic processes in all eukaryotes. However, the functions of ATP-binding cassette (ABC) transporters in iron homeostasis are largely unknown. Here, we found that one ABC transporter (named FgAtm1) is involved in regulating iron homeostasis, by screening sensitivity to iron stress for 60 ABC transporter mutants of Fusarium graminearum, a devastating fungal pathogen of small grain cereal crops worldwide. The lack of FgAtm1 reduces the activity of cytosolic Fe-S proteins nitrite reductase and xanthine dehydrogenase, which causes high expression of FgHapX via activating transcription factor FgAreA. FgHapX represses transcription of genes for iron-consuming proteins directly but activates genes for iron acquisition proteins by suppressing another iron regulator FgSreA. In addition, the transcriptional activity of FgHapX is regulated by the monothiol glutaredoxin FgGrx4. Furthermore, the phosphorylation of FgHapX, mediated by the Ser/Thr kinase FgYak1, is required for its functions in iron homeostasis. Taken together, this study uncovers a novel regulatory mechanism of iron homeostasis mediated by an ABC transporter in an important pathogenic fungus.</div>
</front>
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<DateCompleted><Year>2020</Year>
<Month>01</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>01</Month>
<Day>29</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1553-7374</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>15</Volume>
<Issue>9</Issue>
<PubDate><Year>2019</Year>
<Month>09</Month>
</PubDate>
</JournalIssue>
<Title>PLoS pathogens</Title>
<ISOAbbreviation>PLoS Pathog</ISOAbbreviation>
</Journal>
<ArticleTitle>A fungal ABC transporter FgAtm1 regulates iron homeostasis via the transcription factor cascade FgAreA-HapX.</ArticleTitle>
<Pagination><MedlinePgn>e1007791</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.ppat.1007791</ELocationID>
<Abstract><AbstractText>Iron homeostasis is important for growth, reproduction and other metabolic processes in all eukaryotes. However, the functions of ATP-binding cassette (ABC) transporters in iron homeostasis are largely unknown. Here, we found that one ABC transporter (named FgAtm1) is involved in regulating iron homeostasis, by screening sensitivity to iron stress for 60 ABC transporter mutants of Fusarium graminearum, a devastating fungal pathogen of small grain cereal crops worldwide. The lack of FgAtm1 reduces the activity of cytosolic Fe-S proteins nitrite reductase and xanthine dehydrogenase, which causes high expression of FgHapX via activating transcription factor FgAreA. FgHapX represses transcription of genes for iron-consuming proteins directly but activates genes for iron acquisition proteins by suppressing another iron regulator FgSreA. In addition, the transcriptional activity of FgHapX is regulated by the monothiol glutaredoxin FgGrx4. Furthermore, the phosphorylation of FgHapX, mediated by the Ser/Thr kinase FgYak1, is required for its functions in iron homeostasis. Taken together, this study uncovers a novel regulatory mechanism of iron homeostasis mediated by an ABC transporter in an important pathogenic fungus.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Zhihui</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Rice Biology, Zhejiang University, Hangzhou, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Biotechnology, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ma</LastName>
<ForeName>Tianling</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Rice Biology, Zhejiang University, Hangzhou, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Biotechnology, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Yunyan</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Rice Biology, Zhejiang University, Hangzhou, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Biotechnology, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Jing</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Rice Biology, Zhejiang University, Hangzhou, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Biotechnology, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Yun</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Rice Biology, Zhejiang University, Hangzhou, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Biotechnology, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kistler</LastName>
<ForeName>H Corby</ForeName>
<Initials>HC</Initials>
<Identifier Source="ORCID">0000-0001-5312-6297</Identifier>
<AffiliationInfo><Affiliation>United States Department of Agriculture, Agricultural Research Service, St. Paul, Minnesota, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ma</LastName>
<ForeName>Zhonghua</ForeName>
<Initials>Z</Initials>
<Identifier Source="ORCID">0000-0002-5426-0997</Identifier>
<AffiliationInfo><Affiliation>State Key Laboratory of Rice Biology, Zhejiang University, Hangzhou, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Biotechnology, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yin</LastName>
<ForeName>Yanni</ForeName>
<Initials>Y</Initials>
<Identifier Source="ORCID">0000-0002-0798-3420</Identifier>
<AffiliationInfo><Affiliation>State Key Laboratory of Rice Biology, Zhejiang University, Hangzhou, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Biotechnology, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
<PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>09</Month>
<Day>23</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>PLoS Pathog</MedlineTA>
<NlmUniqueID>101238921</NlmUniqueID>
<ISSNLinking>1553-7366</ISSNLinking>
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<NameOfSubstance UI="D018528">ATP-Binding Cassette Transporters</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D004271">DNA, Fungal</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D005656">Fungal Proteins</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007506">Iron-Sulfur Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D017262">Siderophores</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>E1UOL152H7</RegistryNumber>
<NameOfSubstance UI="D007501">Iron</NameOfSubstance>
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<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D018528" MajorTopicYN="N">ATP-Binding Cassette Transporters</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004271" MajorTopicYN="N">DNA, Fungal</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002523" MajorTopicYN="N">Edible Grain</DescriptorName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
</MeshHeading>
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<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005670" MajorTopicYN="N">Fusarium</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017353" MajorTopicYN="N">Gene Deletion</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005800" MajorTopicYN="N">Genes, Fungal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006706" MajorTopicYN="N">Homeostasis</DescriptorName>
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<MeshHeading><DescriptorName UI="D007501" MajorTopicYN="N">Iron</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
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<MeshHeading><DescriptorName UI="D007506" MajorTopicYN="N">Iron-Sulfur Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008954" MajorTopicYN="N">Models, Biological</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010935" MajorTopicYN="N">Plant Diseases</DescriptorName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017346" MajorTopicYN="N">Protein-Serine-Threonine Kinases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017262" MajorTopicYN="N">Siderophores</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013312" MajorTopicYN="N">Stress, Physiological</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<CoiStatement>The authors from Zhejiang University and the author H. Corby Kistler from United States Department of Agriculture, Agricultural Research Service, St. Paul, Minnesota have declared that no competing interests exist.</CoiStatement>
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A fungal ABC transporter FgAtm1 regulates iron homeostasis via the transcription factor cascade FgAreA-HapX.

A fungal ABC transporter FgAtm1 regulates iron homeostasis via the transcription factor cascade FgAreA-HapX.

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